Strong intrinsic biases towards mutation and conservation of bases in human IgV_H genes during somatic hypermutation prevent statistical analysis of antigen selection

Abstract excerpt

Immunoglobulin V region genes acquire point mutations during affinity maturation of the T-cell-dependent B-cell response. It has been proposed that both selection by antigen and characteristics of the DNA sequence are involved in determining the distribution of mutations along the genes. There is a tendency for replacement mutations to occur in the complementarity-determining regions and for silent mutations to...

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