Article
Enhanced mutational activity and disturbed selection of mutations in V(H) gene rearrangements in a patient with systemic lupus erythematosus.
Autoimmunity - 1 Jan 2000
Jacobi A M, Hansen A, Burmester G R, Dörner T, Lipsky P E
Abstract excerpt
To determine the impact of somatic hypermutation and selective influences on the V(H) gene repertoire in SLE, the mutational frequency and pattern of mutations in nonproductively and productively rearranged V(H) genes obtained from genomic DNA of individual CD19+ B cells were analyzed in a patient with SLE. The mutational frequencies of nonproductive (6.54 x 10(-2)) as well as of productive (4.38 x 10(-2)) V(H)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.