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Article

A new internal ribosomal entry site 5' boundary is required for poliovirus translation initiation in a mouse system.

Journal of virology - 1 Mar 1998

Ishii T, Shiroki K, Hong D H, Aoki T, Ohta Y, Abe S, Hashizume S, Nomoto A

Abstract excerpt

Four mutants of the virulent Mahoney strain of poliovirus were generated by introducing mutations in nucleotides (nt) 128 to 134 of the genome, a region that contains a part of the stem-loop II (SLII) structure located within the internal ribosomal entry site (IRES; nt 120 to 590) (K. Shiroki, T. Ishii, T. Aoki, Y. Ota, W.-X. Yang, T. Komatsu, Y. Ami, M. Arita, S. Abe, S. Hashizume, and A. Nomoto, J. Virol....

Topics

Animals
Binding Sites
Chlorocebus aethiops
Genome, Viral
HeLa Cells
Humans
Mice
Mice, Transgenic
Mutagenesis
Nucleic Acid Conformation
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Poliovirus

Protein Biosynthesis

RNA, Viral

Ribosomes

Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 9499100
DOI: 10.1128/JVI.72.3.2398-2405.1998
PMCID: PMC109539

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9499100-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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