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Activity of a type 1 picornavirus internal ribosomal entry site is determined by sequences within the 3′ nontranslated region

26 Nov 2003

Abstract excerpt

We have proposed a cancer treatment modality based on poliovirus chimeras replicating under the translational control of an internal ribosomal entry site (IRES) derived from human rhinovirus type 2. Insertion of the heterologous IRES causes a neuron-specific propagation deficit and eliminates neurovirulence inherent in poliovirus without affecting viral growth in cells derived from malignant gliomas. We now...

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PMID: 14645707
DOI: 10.1073/pnas.2436464100

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