Molecular genetic analysis of revertants from a poliovirus mutant that is specifically adapted to the mouse spinal cord.

doi:10.1128/JVI.75.23.11766-11772.2001

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Article

Molecular genetic analysis of revertants from a poliovirus mutant that is specifically adapted to the mouse spinal cord.

Journal of virology - 1 Dec 2001

Jia Q, Hogle J M, Hashikawa T, Nomoto A

Abstract excerpt

SA virus, a mutant of the Mahoney strain of type 1 poliovirus (PV1/Mahoney), replicates specifically in the spinal cords of mice and causes paralysis, although the PV1/Mahoney strain does not show any mouse neurovirulence (Q. Jia, S. Ohka, K. Iwasaki, K. Tohyama, and A. Nomoto, J. Virol. 73:6041-...

Topics

Adaptation, Physiological
Animals
Base Sequence
Cell Line
Chlorocebus aethiops
DNA Primers
Genotype
Mice
Mutation
Phenotype
Poliovirus
Reverse Transcriptase Polymerase Chain Reaction
Spinal Cord
Virulence
Virus Replication

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