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Article

Molecular genetic analysis of revertants from a poliovirus mutant that is specifically adapted to the mouse spinal cord.

Journal of virology - 1 Dec 2001

Jia Q, Hogle J M, Hashikawa T, Nomoto A

Abstract excerpt

SA virus, a mutant of the Mahoney strain of type 1 poliovirus (PV1/Mahoney), replicates specifically in the spinal cords of mice and causes paralysis, although the PV1/Mahoney strain does not show any mouse neurovirulence (Q. Jia, S. Ohka, K. Iwasaki, K. Tohyama, and A. Nomoto, J. Virol. 73:6041-6047, 1999). The key mutation site for the mouse neurovirulence of SA was mapped to nucleotide (nt) 928 of the genome...

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Identifiers

PMID: 11689657
DOI: 10.1128/JVI.75.23.11766-11772.2001
PMCID: PMC114762

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