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Article

Minimum internal ribosome entry site required for poliovirus infectivity.

Journal of virology - 1 Dec 1993

Haller A A, Nguyen J H, Semler B L

Abstract excerpt

Translation initiation by internal ribosome binding is a recently discovered mechanism of eukaryotic viral and cellular protein synthesis in which ribosome subunits interact with the mRNAs at internal sites in the 5' untranslated RNA sequences and not with the 5' methylguanosine cap structure present at the extreme 5' ends of mRNA molecules. Uncapped poliovirus mRNAs harbor internal ribosome entry sites (IRES) in...

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Identifiers

PMID: 8230467
DOI: 10.1128/JVI.67.12.7461-7471.1993
PMCID: PMC238212

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