Article
Host range phenotype induced by mutations in the internal ribosomal entry site of poliovirus RNA.
Journal of virology - 1 Jan 1997
Shiroki K, Ishii T, Aoki T, Ota Y, Yang W X, Komatsu T, Ami Y, Arita M, Abe S, Hashizume S, Nomoto A
Abstract excerpt
Most poliovirus strains infect only primates. The host range (HR) of poliovirus is thought to be primarily determined by a cell surface molecule that functions as poliovirus receptor (PVR), since it has been shown that transgenic mice are made poliovirus sensitive by introducing the human PVR gen...
Topics
- Animals
- Base Sequence
- Brain
- Cell Line
- Cell-Free System
- HeLa Cells
- Humans
- Macaca fascicularis
- Mice
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Phenotype
- Poliovirus
- Protein Biosynthesis
- RNA, Viral