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Article

Dual Stem Loops within the Poliovirus Internal Ribosomal Entry Site Control Neurovirulence

1 Feb 1999

Abstract excerpt

In the human central nervous system, susceptibility to poliovirus (PV) infection is largely confined to a specific subpopulation of neuronal cells. PV tropism is likely to be determined by cell-external components such as the PV receptor CD155, as well as cell-internal constraints such as the availability of a suitable microenvironment for virus propagation. We reported previously that the exchange of the cognate...

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PMID: 9882296
DOI: 10.1128/jvi.73.2.958-964.1999

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