IRES Mutation Confers a Replicative Advantage to SVA by Enhancing Translation Efficiency.

doi:10.1155/tbed/7653487

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Article

IRES Mutation Confers a Replicative Advantage to SVA by Enhancing Translation Efficiency.

Transboundary and emerging diseases - 1 Jan 2026

Li Tao, Dang Wen, Li Weiwei, Qin Xiaodong, Xu Fan, Tian Hong, Yang Fan, Chang Yanyan, Zheng Haixue

Abstract excerpt

The internal ribosome entry site (IRES) is a cis-acting element found in certain RNA viruses. In virus-infected cells, the Senecavirus A (SVA) IRES can directly recruit the small ribosomal subunit to an internal initiation codon on the mRNA, enabling translation initiation independently of both the 5' cap structure of the viral genome and the host cell eukaryotic initiation factor 4F (eIF4F). As a small RNA...

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PMID: 42656030
DOI: 10.1155/tbed/7653487
PMCID: PMC13519517

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