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Article

Identification of a substrate-targeting domain in cyclin E necessary for phosphorylation of the retinoblastoma protein.

Proceedings of the National Academy of Sciences of the United States of America - 3 Mar 1998

Kelly B L, Wolfe K G, Roberts J M

Abstract excerpt

Considerable advances have been made in characterizing the cyclins and cyclin-dependent kinases (CDKs) that are necessary for progression through the cell cycle, but there has been relatively lesser success in identifying the specific biochemical pathways and cell cycle events that are directly under CDK control. To identify physiologically significant CDK substrates we generated mutations in cyclin E that...

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Identifiers

PMID: 9482921
DOI: 10.1073/pnas.95.5.2535
PMCID: PMC19404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of a substrate-targeting domain in cyclin E necessary for phosphorylation of the retinoblastoma protein.PMID 9482921Read ↗

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Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4.Semantic proximity Read ↗

PRMT4-mediated arginine methylation negatively regulates retinoblastoma tumor suppressor protein and promotes E2F-1 dissociation.Semantic proximity Read ↗

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