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Identification of CDK2 substrates in human cell lysates

13 Oct 2008

Abstract excerpt

BACKGROUND: Protein phosphorylation regulates a multitude of biological processes. However, the large number of protein kinases and their substrates generates an enormously complex phosphoproteome. The cyclin-dependent kinases--the CDKs--comprise a class of enzymes that regulate cell cycle progression and play important roles in tumorigenesis. However, despite intense study, only a limited number of mammalian CDK...

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PMID: 18847512
DOI: 10.1186/gb-2008-9-10-r149

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