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Article

The extreme COOH terminus of the retinoblastoma tumor suppressor protein pRb is required for phosphorylation on Thr-373 and activation of E2F.

American journal of physiology. Cell physiology - 1 Nov 2008

Gorges Laura L, Lents Nathan H, Baldassare Joseph J

Abstract excerpt

The retinoblastoma protein pRb plays a pivotal role in G(1)- to S-phase cell cycle progression and is among the most frequently mutated gene products in human cancer. Although much focus has been placed on understanding how the A/B pocket and COOH-terminal domain of pRb cooperate to relieve transcriptional repression of E2F-responsive genes, comparatively little emphasis has been placed on the function of the...

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PMID: 18768921
DOI: 10.1152/ajpcell.00300.2008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The extreme COOH terminus of the retinoblastoma tumor suppressor protein pRb is required for phosphorylation on Thr-373 and activation of E2F.PMID 18768921Read ↗

Reverse mutational analysis reveals threonine-373 as a potentially sufficient phosphorylation site for inactivation of the retinoblastoma tumor suppressor protein (pRB).Semantic proximity Read ↗

Structure-function analysis of the retinoblastoma tumor suppressor protein – is the whole a sum of its parts?Semantic proximity Read ↗

The amino terminus of the retinoblastoma (Rb) protein associates with a cyclin-dependent kinase-like kinase via Rb amino acids required for growth suppression.Semantic proximity Read ↗

PRMT4-mediated arginine methylation negatively regulates retinoblastoma tumor suppressor protein and promotes E2F-1 dissociation.Semantic proximity Read ↗

The B-domain lysine patch of pRB is required for binding to large T antigen and release of E2F by phosphorylation.Semantic proximity Read ↗

Post-translational modifications on the retinoblastoma proteinSemantic proximity Read ↗

Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation.Semantic proximity Read ↗

Distinct Mechanisms for Regulating the Tumor Suppressor and Antiapoptotic Functions of RbSemantic proximity Read ↗

Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4.Semantic proximity Read ↗

Retinoblastoma protein binding properties are dependent on 4 cysteine residues in the protein binding pocket.Semantic proximity Read ↗

NF-kappa B-dependent induction of cyclin D1 by retinoblastoma protein (pRB) family proteins and tumor-derived pRB mutants.Semantic proximity Read ↗

Cumulative effect of phosphorylation of pRB on regulation of E2F activity.Semantic proximity Read ↗

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