Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Kinase-independent function of E-type cyclins in liver cancer

16 Jan 2018

Abstract excerpt

E-type cyclins (cyclins E1 and E2) are components of the core cell cycle machinery and are overexpressed in many human tumor types. E cyclins are thought to drive tumor cell proliferation by activating the cyclin-dependent kinase 2 (CDK2). The cyclin E1 gene represents the site of recurrent integration of the hepatitis B virus in the pathogenesis of hepatocellular carcinoma, and this event is associated with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Cancer-related Molecular Pathways
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29339491
DOI: 10.1073/pnas.1711477115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Kinase-independent function of E-type cyclins in liver cancerPMID 29339491Read ↗

Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancerSemantic proximity Read ↗

Cyclin E1 and cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinomaSemantic proximity Read ↗

Targeting Cyclins and Cyclin-Dependent Kinases in Cancer: Lessons from Mice, Hopes for Therapeutic Applications in HumansSemantic proximity Read ↗

Constitutive turnover of cyclin E by Cul3 maintains quiescence.Semantic proximity Read ↗

Promiscuity rules? The dispensability of cyclin E and Cdk2.Semantic proximity Read ↗

The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein.Semantic proximity Read ↗

Cdk2 is Required for Breast Cancer Mediated by the Low-Molecular-Weight Isoform of Cyclin ESemantic proximity Read ↗

Rescue of cyclin D1 deficiency by knockin cyclin E.Semantic proximity Read ↗

Expression of cyclins E1 and E2 during mouse development and in neoplasiaSemantic proximity Read ↗

The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cellsSemantic proximity Read ↗

Cyclin E Transgenic Mice: Discovery Tools for Lung Cancer Biology, Therapy, and PreventionSemantic proximity Read ↗

Cyclin E2, a Novel G1 Cyclin That Binds Cdk2 and Is Aberrantly Expressed in Human CancersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.