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Article

PRMT4-mediated arginine methylation negatively regulates retinoblastoma tumor suppressor protein and promotes E2F-1 dissociation.

Molecular and cellular biology - 1 Jan 2015

Kim Kevin Y, Wang Don-Hong, Campbell Mel, Huerta Steve B, Shevchenko Bogdan, Izumiya Chie, Izumiya Yoshihiro

Abstract excerpt

The retinoblastoma protein (pRb/p105) tumor suppressor plays a pivotal role in cell cycle regulation by blockage of the G1-to-S-phase transition. pRb tumor suppressor activity is governed by a variety of posttranslational modifications, most notably phosphorylation by cyclin-dependent kinase (Cdk) complexes. Here we report a novel regulation of pRb through protein arginine methyltransferase 4 (PRMT4)-mediated...

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Share to Arginine
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to E2F1 Transcription Factor

Share to HEK293 Cells

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Source

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Identifiers

PMID: 25348716
DOI: 10.1128/MCB.00945-14
PMCID: PMC4295381

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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PRMT4-mediated arginine methylation negatively regulates retinoblastoma tumor suppressor protein and promotes E2F-1 dissociation.PMID 25348716Read ↗

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