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Article

The B-domain lysine patch of pRB is required for binding to large T antigen and release of E2F by phosphorylation.

Molecular and cellular biology - 1 Mar 2002

Brown Vivette D, Gallie Brenda L

Abstract excerpt

Cell cycle-dependent, site-specific phosphorylation of the retinoblastoma protein, pRB, is mediated by cyclin-dependent kinases (CDKs) and regulates the binding of pRB to many proteins. We previously showed that the interaction of pRB with E2F on DNA was regulated by the accumulation of phosphate groups on pRB. Here we show that positively charged lysine residues in the B domain of pRB are necessary for the...

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Share to Acetylation
Share to Antigens, Polyomavirus Transforming
Share to Cyclin E

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to E2F Transcription Factors

Share to Histone Deacetylase 1

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Source

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Identifiers

PMID: 11839806
DOI: 10.1128/MCB.22.5.1390-1401.2002
PMCID: PMC134706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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