Article
Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase.
Cellular signalling - 1 Nov 2012
Shehata Saifeldin N, Hunter Roger W, Ohta Eriko, Peggie Mark W, Lou Hua Jane, Sicheri Frank, Zeqiraj Elton, Turk Benjamin E, Sakamoto Kei
Abstract excerpt
PCTAIRE-1 (cyclin-dependent kinase [CDK] 16) is a highly conserved serine/threonine kinase that belongs to the CDK family of protein kinases. Little is known regarding PCTAIRE-1 regulation and function and no robust assay exists to assess PCTAIRE-1 activity mainly due to a lack of information regarding its preferred consensus motif and the lack of bona fide substrates. We used positional scanning peptide library...
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