Article
Structure-function analysis of the retinoblastoma tumor suppressor protein – is the whole a sum of its parts?
1 Jan 2007
Abstract excerpt
Biochemical analysis of the retinoblastoma protein's function has received considerable attention since it was cloned just over 20 years ago. During this time pRB has emerged as a key regulator of the cell division cycle and its ability to block proliferation is disrupted in the vast majority of human cancers. Much has been learned about the regulation of E2F transcription factors by pRB in the cell cycle....
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