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Article

Cyclin E and Its Low Molecular Weight Forms in Human Cancer and as Targets for Cancer Therapy

1 Mar 2003

Abstract excerpt

The progression of a cell through the cell cycle is promoted by cyclin dependent kinases (CDKs), which are positively regulated by cyclins and negatively regulated by CDK inhibitors. D type cyclins interact with CDK4 and CDK6 to drive the progression of a cell through early/mid-G(1)in response to mitogen stimulation. The association of cyclin E with CDK2 forms an active complex in late G(1) that directs entry...

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PMID: 14508079
DOI: 10.4161/cbt.201

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