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Article

Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4.

The Journal of biological chemistry - 26 Jul 2002

Farkas Thomas, Hansen Klaus, Holm Karin, Lukas Jiri, Bartek Jiri

Abstract excerpt

The "pocket proteins" pRb (retinoblastoma tumor suppressor protein), p107, and p130 regulate cell proliferation via phosphorylation-sensitive interactions with E2F transcription factors and other proteins. We previously identified 22 in vivo phosphorylation sites in human p130, including three sites selectively targeted by cyclin D-Cdk4(6) kinases. Here we assessed the effects of alanine substitution at the...

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Identifiers

PMID: 12006580
DOI: 10.1074/jbc.M200381200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4.PMID 12006580Read ↗

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Cumulative effect of phosphorylation of pRB on regulation of E2F activity.Semantic proximity Read ↗

In vitro phosphorylation and acetylation of the murine pocket protein Rb2/p130.Semantic proximity Read ↗

Stabilization of GTSE1 by cyclin D1–CDK4/6-mediated phosphorylation promotes cell proliferation with implications for cancer prognosisSemantic proximity Read ↗

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The extreme COOH terminus of the retinoblastoma tumor suppressor protein pRb is required for phosphorylation on Thr-373 and activation of E2F.Semantic proximity Read ↗

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