Article
Gender effect on apolipoprotein E epsilon4 allele-associated risk for sporadic Alzheimer's disease.
Acta neurologica Scandinavica - 1 Jan 1998
Combarros O, Leno C, Oterino A, Berciano J, Fernández-Luna J L, Fernández-Viadero C, Peña N, Miró J, Delgado M
Abstract excerpt
INTRODUCTION: The role of gender in Alzheimer's disease (AD), and its possible interaction with apolipoprotein E (apoE), has been controversial. MATERIAL AND METHODS: ApoE allelic frequencies and the effect of apoE epsilon4 allele dosage on risk and age at onset of AD were evaluated, separately for men and women, in 100 patients with sporadic AD and 100 age-matched controls. RESULTS: The distribution of apoE...
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