Article
Apolipoprotein E genotype in sporadic early- and late-onset Alzheimer's disease.
Dementia and geriatric cognitive disorders - 1 Jan 2000
Masullo C, Daniele A, Seripa D, Filippini V, Gravina C, Carbone G, Gainotti G, Fazio V M
Abstract excerpt
The 84 isoform of apolipoprotein E (ApoE) has been proposed as a risk factor for Alzheimer's disease (AD), while the possible role of the epsilon2 allele in AD is controversial. We have studied the ApoE genotype in 38 patients with early-onset AD (EOAD) and in 43 patients with late-onset AD (LOAD). In the EOAD group we observed a significant increase of epsilon4 allele frequency as compared with normal controls,...
Topics
- Age of Onset
- Aged
- Alzheimer Disease
- Apolipoproteins E
- Female
- Genotype
- Heterozygote
- Humans
- Male
- Middle Aged