Article
Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease.
Nature genetics - 1 Jun 1994
Corder E H, Saunders A M, Risch N J, Strittmatter W J, Schmechel D E, Gaskell P C, Rimmler J B, Locke P A, Conneally P M, Schmader K E
Abstract excerpt
Gene dosage of the apolipoprotein E (APOE) epsilon 4 allele is a major risk factor for familial Alzheimer disease (AD) of late onset (after age 60). Here we studied a large series of 115 AD case subjects and 243 controls as well as 150 affected and 197 unaffected members of 66 AD families. Our data demonstrate a protective effect of the epsilon 2 allele, in addition to the dose effect of the epsilon 4 allele in...
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