Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease.

doi:10.1038/ng0694-180

Article

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease.

Nature genetics - 1 Jun 1994

Corder E H, Saunders A M, Risch N J, Strittmatter W J, Schmechel D E, Gaskell P C, Rimmler J B, Locke P A, Conneally P M, Schmader K E

Abstract excerpt

Gene dosage of the apolipoprotein E (APOE) epsilon 4 allele is a major risk factor for familial Alzheimer disease (AD) of late onset (after age 60). Here we studied a large series of 115 AD case subjects and 243 controls as well as 150 affected and 197 unaffected members of 66 AD families. Our da...

Topics

Age of Onset
Aged
Alleles
Alzheimer Disease
Apolipoproteins E
Female
Gene Frequency
Genotype
Humans
Male
Middle Aged
Odds Ratio
Risk Factors

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.