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Article

Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex.

American journal of human genetics - 1 Feb 1997

Bickeböller H, Campion D, Brice A, Amouyel P, Hannequin D, Didierjean O, Penet C, Martin C, Pérez-Tur J, Michon A, Dubois B, Ledoze F, Thomas-Anterion C, Pasquier F, Puel M, Demonet J F, Moreaud O, Babron M C, Meulien D, Guez D, Chartier-Harlin M C, Frebourg T, Agid Y, Martinez M, Clerget-Darpoux F

Abstract excerpt

The distribution of apolipoprotein E (APOE) genotypes as a function of age and sex has been examined in a French population of 417 Alzheimer disease (AD) patients and 1,030 control subjects. When compared to the APOE epsilon3 allele, an increased risk associated with the APOE epsilon4 allele (odds ratio [OR] [epsilon4] = 2.7 with 95% confidence interval [CI] = 2.0-3.6; P < .001) and a protective effect of the...

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Identifiers

PMID: 9012418
PMCID: PMC1712413

Genes

APOE

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Source receipt: pubmed, retrieved 7 Sept 2026.

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