Article
The apolipoprotein E epsilon4 allele selectively increases the risk of frontotemporal lobar degeneration in males.
Journal of neurology, neurosurgery, and psychiatry - 1 Feb 2006
Srinivasan R, Davidson Y, Gibbons L, Payton A, Richardson A M T, Varma A, Julien C, Stopford C, Thompson J, Horan M A, Pendleton N, Pickering-Brown S M, Neary D, Snowden J S, Mann D M A
Abstract excerpt
OBJECTIVE: To determine whether polymorphic variations in the apolipoprotein E gene (APOE) are associated with increased risk of frontotemporal lobar degeneration (FTLD) when mutation in tau gene is absent. METHODS: The APOE gene was genotyped by polymerase chain reaction from DNA routinely extracted from blood or brain tissues. The APOE epsilon4 allele frequency in 198 patients with FTLD not associated with...
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