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Article

Evidence for an interaction between apolipoprotein E genotype, gender, and Alzheimer disease.

Alzheimer disease and associated disorders - 1 Jan 2000

Bretsky P M, Buckwalter J G, Seeman T E, Miller C A, Poirier J, Schellenberg G D, Finch C E, Henderson V W

Abstract excerpt

Carriers of the apolipoprotein E (APOE) epsilon4 allele show significantly higher risk of Alzheimer disease (AD). The aim of this present study was to test the hypothesis that a significant interaction exists between APOE genotype and gender on AD. Interactions of epsilon4 by gender, although indicated in the literature, require further verification. A total of 195 past or current control or AD participants in an...

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Source

Identifiers

PMID: 10609670
DOI: 10.1097/00002093-199910000-00007

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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