Article
Mutation detection and typing of polymorphic loci through double-strand conformation analysis.
Nature genetics - 1 Feb 1998
Argüello J R, Little A M, Pay A L, Gallardo D, Rojas I, Marsh S G, Goldman J M, Madrigal J A
Abstract excerpt
Variations, such as nucleotide substitutions, deletions and insertions, within genes can affect the function of the gene product and in some cases be deleterious. Screening for known allelic variation is important for determining disease and gene associations. Techniques which target specific mut...
Topics
- DNA
- Electrophoresis, Polyacrylamide Gel
- Genetic Carrier Screening
- HLA-A Antigens
- Histocompatibility Antigens Class I
- Humans
- Mutation
- Nucleic Acid Conformation
- Polymerase Chain Reaction
- Polymorphism, Genetic