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Article

Single-strand conformation polymorphism and heteroduplex analysis for gel-based mutation detection.

Electrophoresis - 1 Jun 1999

Nataraj A J, Olivos-Glander I, Kusukawa N, Highsmith W E

Abstract excerpt

Single-strand conformation polymorphism (SSCP) and heteroduplex analysis (HA) are popular electrophoretic methods for the identification of sequences. The principle reasons for the popularity of these two methods are their technical simplicity and their relatively high sensitivity for the detection of mutations. Here we review the theory and practice of SSCP and HA, including the factors contributing to the...

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Identifiers

PMID: 10380757
DOI: 10.1002/(SICI)1522-2683(19990101)20:6<1177::AID-ELPS1177>3.0.CO;2-2

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