Article
High-throughput conformation-sensitive gel electrophoresis for discovery of SNPs.
BioTechniques - 1 Feb 2001
Leung Y F, Tam P O, Tong W C, Baum L, Choy K W, Lam D S, Pang C P
Abstract excerpt
High-throughput screening for single nucleotide polymorphisms (SNPs) or mutations can be achieved by inexpensive technologies. We modified the original protocols of conformation-sensitive gel electrophoresis (CSGE) to increase throughput several fold to 1.3 samples/min, which is about five times faster than denaturing high-performance liquid chromatography (DHPLC). The modifications include decreasing the gel...
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