Article
Rapid detection of DNA sequence variants by conformation-sensitive capillary electrophoresis.
Genomics - 15 Nov 2000
Rozycka M, Collins N, Stratton M R, Wooster R
Abstract excerpt
The identification of novel sequence variants, which may be either disease-causing mutations or silent polymorphisms, in large numbers of samples is becoming the rate-limiting step in associating diseases with specific genes. This is particularly true in light of the imminent arrival of the complete reference sequence of the human genome. A number of techniques have been developed to analyze DNA samples for...
Topics
- BRCA2 Protein
- DNA
- Electrophoresis, Capillary
- Genetic Variation
- Humans
- Lipoprotein Lipase
- Neoplasm Proteins
- Nucleic Acid Conformation
- Sequence Analysis, DNA
- Transcription Factors