Article
An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination.
Nature genetics - 1 Feb 1998
Meyers E N, Lewandoski M, Martin G R
Abstract excerpt
We describe a strategy for generating an allelic series of mutations at a given locus that requires the production of only one targetted mouse line. The 'allelogenic' mouse line we produced carries a hypomorphic allele of Fgf8, which can be converted to a null allele by mating to cre transgenic animals. The hypomorphic allele can also be reverted to wild-type by mating the allelogenic mice to flp transgenic...
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