Article
Generation of an Fgf9 conditional null allele.
Genesis (New York, N.Y. : 2000) - 1 Mar 2006
Lin Yongshun, Liu Guoqin, Wang Fen
Abstract excerpt
The fibroblast growth factor (FGF) family consists of 22 widely expressed regulatory polypeptides and controls a broad spectrum of cellular processes. Accumulating data show that FGF9 plays important roles both in embryogenesis and in adult tissue homeostasis. Ablation of Fgf9 alleles leads to lethality at the neonatal stage mainly due to malformations of the lung, as well as causing male-to-female sex reversal....
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