Article
Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles.
Current biology : CB - 21 May 1998
Nagy A, Moens C, Ivanyi E, Pawling J, Gertsenstein M, Hadjantonakis A K, Pirity M, Rossant J
Abstract excerpt
The N-myc proto-oncogene is expressed in many organs of the mouse embryo, suggesting that it has multiple functions. A null mutation leads to mid-gestation lethality [1-4], obscuring the later roles of the gene in organogenesis. We have generated a multi-purpose gene alteration by combining the potential for homologous and site-specific recombination in a single targeting vector, and using the selectable marker...
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