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Article

F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses.

Nature biotechnology - 1 Jan 2007

Poueymirou William T, Auerbach Wojtek, Frendewey David, Hickey Joseph F, Escaravage Jennifer M, Esau Lakeisha, Doré Anthony T, Stevens Sean, Adams Niels C, Dominguez Melissa G, Gale Nicholas W, Yancopoulos George D, DeChiara Thomas M, Valenzuela David M

Abstract excerpt

A useful approach for exploring gene function involves generating mutant mice from genetically modified embryonic stem (ES) cells. Recent advances in genetic engineering of ES cells have shifted the bottleneck in this process to the generation of mice. Conventional injections of ES cells into blastocyst hosts produce F0 generation chimeras that are only partially derived from ES cells, requiring additional...

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PMID: 17187059
DOI: 10.1038/nbt1263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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