Article

A CRISPR toolbox for generating intersectional genetic mice for functional, molecular, and anatomical circuit mapping

2021-06-10

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> A full understanding of circuits and cellular mechanisms governing health and disease requires the dissection and multi-faceted study of discrete cell subtypes in developing and adult animal models. Recombinase-driven expression of transgenic response alleles represents a significant and powerful approach to delineate cell populations for functional, molecular, and anatomica...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 799335c1-b5b5-57eb-a066-ac7217424428
DOI: 10.1101/2021.06.10.447908

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A CRISPR toolbox for generating intersectional genetic mice for functional, molecular, and anatomical circuit mappingDOI 10.1101/2021.06.10.447908Read

Expanding the power of recombinase-based labeling to uncover cellular diversity.Semantic proximity Read

Generating mouse lines for lineage tracing and knockout studies.Semantic proximity Read

Recombinase-Dependent Mouse Lines for Chemogenetic Activation of Genetically Defined Cell Types.Semantic proximity Read

A suite of enhancer AAVs and transgenic mouse lines for genetic access to cortical cell typesSemantic proximity Read

When reverse genetics meets physiology: the use of site-specific recombinases in mice.Semantic proximity Read

Phenotypic analysis with trans-recombination-based genetic mosaic models.Semantic proximity Read

Universal method for generating knockout mice in multiple genetic backgrounds using zygote electroporationSemantic proximity Read

Recovering a Targeted Mutation in Mice from Embryonic Stem Cell Chimeras or CRISPR-Cas Founders.Semantic proximity Read

One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs.Semantic proximity Read

Generation of mouse conditional knockout alleles in one step using the i-GONAD method.Semantic proximity Read

Genome-scale CRISPR screening in a single mouse liverSemantic proximity Read

Cell specific single viral vector CRISPR/Cas9 editing and genetically encoded tool delivery in the central and peripheral nervous systemsSemantic proximity Read