Article
In vivo and in vitro generation of a new altered HLA phenotype in melanoma-tumour-cell variants expressing a single HLA-class-I allele.
International journal of cancer - 19 Jan 1998
Real L M, Jimenez P, Cantón J, Kirkin A, García A, Abril E, Zeuthen J, Ruiz-Cabello F, Garrido F
Abstract excerpt
A new HLA-class-I altered phenotype is described in melanoma. This phenotype is the result of a combination of HLA-B-locus down-regulation and HLA-haplotype loss. The alteration was found in 2 melanoma cell lines generated from 2 patients; one was derived from an in vivo lesion (FM37) and the oth...
Topics
- Alleles
- Genes, MHC Class I
- HLA-A2 Antigen
- HLA-B Antigens
- Humans
- Interferon-gamma
- Melanoma
- Phenotype
- T-Lymphocytes, Cytotoxic
- Tumor Cells, Cultured