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Article

Immune escape of cancer cells with beta2-microglobulin loss over the course of metastatic melanoma.

International journal of cancer - 1 Jan 2014

del Campo Ana B, Kyte Jon Amund, Carretero Javier, Zinchencko Svitlana, Méndez Rosa, González-Aseguinolaza Gloria, Ruiz-Cabello Francisco, Aamdal Steinar, Gaudernack Gustav, Garrido Federico, Aptsiauri Natalia

Abstract excerpt

Cancer cells escape T-cell-mediated destruction by losing human leukocyte antigen (HLA) class I expression via various mechanisms, including loss of beta2-microglobulin (β2m). Our study illustrates the immune escape of HLA class I-negative tumor cells and chronological sequence of appearance of tumor β2m gene mutation in successive lesions obtained from a patient with metastatic melanoma. We observed a gradual...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23784959
DOI: 10.1002/ijc.28338

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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