Article
Low prevalence of selective human leukocyte antigen (HLA)-A and HLA-B epitope losses in early-passage tumor cell lines.
Cancer research - 1 Jun 1999
Giacomini P, Giorda E, Fraioli R, Nicotra M R, Vitale N, Setini A, Delfino L, Morabito A, Benevolo M, Venturo I, Mottolese M, Ferrara G B, Natali P G
Abstract excerpt
The down-regulation of human leukocyte antigen (HLA) class I molecules, especially the selective down-regulation of certain allelic products, is believed to represent a major mechanism of tumor escape from immune surveillance. In the present report, an original approach is described to precisely evaluate and classify HLA class I epitope losses in 30 cancer patients with malignant melanoma and lung, breast,...
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