Loss of single HLA class I allospecificities in melanoma cells due to selective genomic abbreviations.

doi:10.1002/ijc.10284

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Article

Loss of single HLA class I allospecificities in melanoma cells due to selective genomic abbreviations.

International journal of cancer - 1 May 2002

Geertsen Ralf, Böni Roland, Blasczyk Rainer, Romero Pedro, Betts David, Rimoldi Donata, Hong Xin, Laine Elisabeth, Willers Jörg, Dummer Reinhard

Abstract excerpt

Expression of human leucocyte antigen (HLA) Class I molecules is essential for the recognition of malignant melanoma (MM) cells by CD8(+) T lymphocytes. A complete or partial loss of HLA Class I molecules is a potent strategy for MM cells to escape from immunosurveillance. In 2 out of 55 melanoma cell cultures we identified a complete phenotypic loss of HLA allospecificities. Both patients have been treated...

Topics

Alleles
Antigens, Neoplasm
Chromosomes, Human, Pair 6
Flow Cytometry
Genes, MHC Class I
HLA-A2 Antigen
Humans
Karyotyping
Loss of Heterozygosity
Melanoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Polymerase Chain Reaction

Polymorphism, Single-Stranded Conformational

Sequence Analysis, DNA

Skin Neoplasms

T-Lymphocytes, Cytotoxic

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 11948496
DOI: 10.1002/ijc.10284

Provenance

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