Loss of HLA haplotype and B locus down-regulation in melanoma cell lines.

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Article

Loss of HLA haplotype and B locus down-regulation in melanoma cell lines.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 1994

Marincola F M, Shamamian P, Alexander R B, Gnarra J R, Turetskaya R L, Nedospasov S A, Simonis T B, Taubenberger J K, Yannelli J, Mixon A

Abstract excerpt

The expression of HLA class I molecules on tumor cells is vital for CD8+T cell recognition of tumor Ags. Loss of HLA class I Ag expression as a result of defective beta 2-microglobulin genes has been described in melanoma cells. To further evaluate mechanisms of tumor escape, HLA class I Ag expre...

Topics

Alleles
Base Sequence
Cell Line
DNA Primers
Gene Expression Regulation, Neoplastic
HLA Antigens
Haplotypes
Humans
Interferon-gamma
Melanoma
Molecular Sequence Data
RNA, Messenger
Repetitive Sequences, Nucleic Acid
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 8027550

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8027550-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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