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Article

Loss of HLA haplotype and B locus down-regulation in melanoma cell lines.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 1994

Marincola F M, Shamamian P, Alexander R B, Gnarra J R, Turetskaya R L, Nedospasov S A, Simonis T B, Taubenberger J K, Yannelli J, Mixon A

Abstract excerpt

The expression of HLA class I molecules on tumor cells is vital for CD8+T cell recognition of tumor Ags. Loss of HLA class I Ag expression as a result of defective beta 2-microglobulin genes has been described in melanoma cells. To further evaluate mechanisms of tumor escape, HLA class I Ag expression was compared in 24 metastatic melanoma cell lines and 20 melanocyte strains by FACS analysis with use of...

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PMID: 8027550

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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