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Article

High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity.

Cancer immunology, immunotherapy : CII - 1 Feb 2005

Rodriguez Teresa, Méndez Rosa, Roberts Chrissy H, Ruiz-Cabello Francisco, Dodi I Anthony, López Nevot Miguel Angel, Paco Laura, Maleno Isabel, Marsh Steven G E, Pawelec Graham, Garrido Federico

Abstract excerpt

Malignant transformation of cells is frequently associated with abnormalities in human leukocyte antigen (HLA) expression. MHC class I loss or down-regulation in cancer cells is a major immune escape route used by a large variety of human tumours to evade antitumour immune responses mediated by cytotoxic T lymphocytes. The goal of our study was to explore HLA genotyping and phenotyping in a variety of melanoma...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15592718
DOI: 10.1007/s00262-004-0561-5
PMCID: PMC11032966

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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