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Article

Natural variation of the expression of HLA and endogenous antigen modulates CTL recognition in an in vitro melanoma model.

International journal of cancer - 1 Mar 1999

Cormier J N, Panelli M C, Hackett J A, Bettinotti M P, Mixon A, Wunderlich J, Parker L L, Restifo N P, Ferrone S, Marincola F M

Abstract excerpt

Increasing attention has been devoted to elucidating the mechanism of lost or decreased expression of MHC or melanoma-associated antigens (MAAs), which may lead to tumor escape from immune recognition. Loss of expression of HLA class I or MAA has, as an undisputed consequence, loss of recognition by HLA class I-restricted cytotoxic T cells (CTLs). However, the relevance of down-regulation remains in question in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10048982
DOI: 10.1002/(sici)1097-0215(19990301)80:5<781::aid-ijc24>3.0.co;2-a
PMCID: PMC2072935

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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