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Article

FHIT gene abnormalities in both benign and malignant thyroid tumours.

European journal of cancer (Oxford, England : 1990) - 1 Mar 1999

Zou M, Shi Y, Farid N R, al-Sedairy S T, Paterson M C

Abstract excerpt

FHIT, a candidate tumour suppressor gene, has recently been identified at chromosomal region 3p14.2, and deletions of the gene have been reported in many types of human cancers. Loss of heterozygosity (LOH) at this region has also been found frequently in follicular thyroid carcinoma (FTC). To in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10448301
DOI: 10.1016/s0959-8049(98)00370-0

Genes

FHIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10448301-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FHIT gene abnormalities in both benign and malignant thyroid tumours.PMID 10448301Read ↗

Aberrant FHIT transcripts in squamous cell carcinoma of the uterine cervix.Semantic proximity Read ↗

Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions.Semantic proximity Read ↗

Homozygous deletion but not mutation of exons 5 and 8 of the fragile histidine triad (FHIT) gene is associated with features of differentiated thyroid carcinoma.Semantic proximity Read ↗

FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations.Semantic proximity Read ↗

HPV-associated cervical cancers show frequent allelic loss at 3p14 but no apparent aberration of FHIT mRNA.Semantic proximity Read ↗

FHIT alterations in breast cancer.Semantic proximity Read ↗

fhit Alterations in endometrial carcinoma and hyperplasia.Semantic proximity Read ↗

Aberration of FHIT gene is associated with increased tumor proliferation and decreased apoptosis-clinical evidence in lung and head and neck carcinomas.Semantic proximity Read ↗

Frequent allelic deletion at the FHIT locus associated with p53 overexpression in squamous cell carcinoma subtype of Taiwanese non-small-cell lung cancers.Semantic proximity Read ↗

The expression of Fhit protein is related inversely to disease progression in patients with breast carcinomaSemantic proximity Read ↗

Allelic deletion analysis of the FHIT gene predicts poor survival in non-small cell lung cancer.Semantic proximity Read ↗

Frequent silencing of RASSF1A via promoter methylation in follicular thyroid hyperplasia: a potential early epigenetic susceptibility event in thyroid carcinogenesis.Semantic proximity Read ↗

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