Loss of heterozygosity at the short arm of chromosome 3 in microdissected cervical intraepithelial neoplasia.

doi:10.1016/s0304-3835(00)00398-0

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Article

Loss of heterozygosity at the short arm of chromosome 3 in microdissected cervical intraepithelial neoplasia.

Cancer letters - 30 Jun 2000

Chung T K, Cheung T H, Lo W K, Yu M Y, Hampton G M, Wong H K, Wong Y F

Abstract excerpt

Loss of heterozygosity (LOH) is a common genetic finding in many human neoplasms, including cervical cancer. The detection of LOH at specific loci in the precursor of cervical cancer, cervical intraepithelial neoplasia (CIN) may help in elucidating the evolution of this cancer, which has a clearly defined histological premalignant phase. However, molecular genetic investigation of CIN is difficult because many of...

Topics

Alleles
Chromosomes, Human, Pair 3
Female
Genotype
Humans
Loss of Heterozygosity
Microsatellite Repeats
Polymerase Chain Reaction
Uterine Cervical Neoplasms
Uterine Cervical Dysplasia

Source

Open in PubMed

Identifiers

PMID: 10806307
DOI: 10.1016/s0304-3835(00)00398-0

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