Article
FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations.
Cancer research - 1 Jun 1997
Fong K M, Biesterveld E J, Virmani A, Wistuba I, Sekido Y, Bader S A, Ahmadian M, Ong S T, Rassool F V, Zimmerman P V, Giaccone G, Gazdar A F, Minna J D
Abstract excerpt
We evaluated primary lung cancers, tumor cell lines, and preneoplastic bronchial lesions for molecular genetic abnormalities in the candidate tumor suppressor gene FHIT, which spans the FRA3B fragile site at 3p14.2. 3p14.2 allele loss was very frequent in 32 lung cancer cell lines [100% of small cell lung cancer and 88% of non-small cell lung cancer (NSCLC)] and 108 primary NSCLC cancers (45%), with numerous...
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