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Article

The molecular genetics of cervical carcinoma

30 Jul 1999

Abstract excerpt

In the pathogenesis of cervical carcinoma there are three major components, two of them related to the role of human papillomaviruses (HPV). First, the effect of viral E6 and E7 proteins. Second, the integration of viral DNA in chromosomal regions associated with well known tumour phenotypes. Some of these viral integrations occur recurrently at specific chromosomal locations, such as 8q24 and 12q15, both...

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PMID: 10471054
DOI: 10.1038/sj.bjc.6690635

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