Article
Deletions of chromosome 3p are frequent and early events in the pathogenesis of uterine cervical carcinoma.
Cancer research - 1 Aug 1997
Wistuba I I, Montellano F D, Milchgrub S, Virmani A K, Behrens C, Chen H, Ahmadian M, Nowak J A, Muller C, Minna J D, Gazdar A F
Abstract excerpt
To study the molecular abnormalities involved in the multistage development of cervical carcinoma (CC), we investigated the presence of oncogenic human papillomavirus (HPV) sequences, loss of heterozygosity (LOH), and microsatellite alterations at several genes/loci at 3p (3p14.2 at the FHIT gene, 3p14.3-21.1, 3p21, and 3p22-24.2), 9p21, RB and P53, and P53 gene point mutations in precisely microdissected...
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