Article
Chromosome 3p tumor-suppressor gene alterations in cervical carcinomas.
Molecular carcinogenesis - 1 Mar 2001
Herzog C R, Crist K A, Sabourin C L, Kelloff G J, Boone C W, Stoner G D, You M
Abstract excerpt
Loss of heterozygosity (LOH) on chromosome 3p is a common event in cervical cancer and typically occurs in a dispersed pattern involving several loci. This implies that more than one resident tumor-suppressor gene is involved in the genesis of these tumors; however, specific targets remain to be identified. The region of 3p14.2-pter encompasses a region of frequent loss and contains at least three...
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