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Article

Fibroblast variants nonresponsive to fibroblast growth factor 1 are defective in its nuclear translocation.

The Journal of biological chemistry - 13 Feb 1998

Mehta V B, Connors L, Wang H C, Chiu I M

Abstract excerpt

Fibroblast growth factors (FGF) elicit biological effects by binding to high affinity cell-surface receptors and activation of receptor tyrosine kinase. We previously reported that two NIH/3T3 derivatives, NR31 and NR33 (NR cells), express high levels of full-length FGF-1 and exhibit a complete spectrum of transformed phenotype. In the present study, we report that NR cells respond to the mitogenic stimulation of...

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PMID: 9461616
DOI: 10.1074/jbc.273.7.4197

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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