Article
Epidermal growth factor (EGF)-nonresponsive variants of normal rat kidney cell line: response to EGF and transforming growth factor-beta.
Experimental cell research - 1 Jan 1990
Hamanaka R, Ono M, Kuratomi Y, Mizoguchi H, Hirai R, Kohno K, Kuwano M
Abstract excerpt
Anchorage-independent growth in soft agar of normal rat kidney (NRK) fibroblasts depends on both transforming growth factor-beta (TGF-beta) and epidermal growth factor (EGF) (or TGF-alpha). We have isolated two EGF-nonresponsive cell lines, N-3 and N-9, from chemically mutagenized NRK cells, afte...
Topics
- Animals
- Cell Line
- Cell Separation
- DNA
- Epidermal Growth Factor
- ErbB Receptors
- Fibroblasts
- Gene Expression
- Genetic Variation
- Glucose
- Kidney
- Phosphorylation
- Rats
- Transforming Growth Factors
- Tyrosine