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Article

Epidermal growth factor (EGF)-nonresponsive variants of normal rat kidney cell line: response to EGF and transforming growth factor-beta.

Experimental cell research - 1 Jan 1990

Hamanaka R, Ono M, Kuratomi Y, Mizoguchi H, Hirai R, Kohno K, Kuwano M

Abstract excerpt

Anchorage-independent growth in soft agar of normal rat kidney (NRK) fibroblasts depends on both transforming growth factor-beta (TGF-beta) and epidermal growth factor (EGF) (or TGF-alpha). We have isolated two EGF-nonresponsive cell lines, N-3 and N-9, from chemically mutagenized NRK cells, after selection of mitogen-specific nonproliferative variants in the presence of EGF and colchicine. Saturation binding...

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Source

Identifiers

PMID: 2298239
DOI: 10.1016/0014-4827(90)90213-t

Genes

EGF
NRK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Epidermal growth factor (EGF)-nonresponsive variants of normal rat kidney cell line: response to EGF and transforming growth factor-beta.PMID 2298239Read ↗

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Role of TGF-beta in EGF-induced transformation of NRK cells is sustaining high-level EGF-signaling.Semantic proximity Read ↗

Oncogenic signal-induced ability to enter S phase in the absence of anchorage is the mechanism for the growth of transformed NRK cells in soft agar.Semantic proximity Read ↗

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Phenotypic transformation of normal rat kidney cells by transforming growth factor beta is not paralleled by enhanced production of a platelet-derived growth factor.Semantic proximity Read ↗

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Role of a signal transduction pathway which controls disassembly of microfilament bundles and suppression of high-molecular-weight tropomyosin expression in oncogenic transformation of NRK cells.Semantic proximity Read ↗

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