Article
Selective expression of high molecular weight basic fibroblast growth factor confers a unique phenotype to NIH 3T3 cells.
Cell regulation - 1 Sept 1991
Quarto N, Talarico D, Florkiewicz R, Rifkin D B
Abstract excerpt
The phenotypes of NIH 3T3 cells transfected with basic fibroblast growth factor (bFGF) cDNAs that express only the high molecular weight (HMW) forms of bFGF, the 18-kDa form, or all forms were examined. Cells producing the 18 kDa or all forms of bFGF were transformed at high levels of growth factor expression but were nontransformed at low levels. Cell producing low levels of HMW forms of bFGF were growth...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Binding Sites
- Blotting, Southern
- Cell Division
- Cell Transformation, Neoplastic
- Culture Media
- DNA
- Fibroblast Growth Factor 2
- Giant Cells